Nitric oxide regulation is one of the most studied problems in physiology and medicine, and it’s an issue with far-reaching implications for weight management, exercise performance and overall health. Nitric oxide (NO) is an important signaling chemical produced by the endothelial cells lining the blood vessels that regulates blood flow. NO metabolism is regarded as one of the best markers of metabolic health and is critical for disease prevention, sexual performance and longevity. Endothelial cell dysfunction is linked to cardiovascular disease, poor energy levels and depression.

A review of literature by Brian Sansbury and Bradford Hill from the University of Louisville concluded that NO is very important for the regulation of body fat, obesity and insulin metabolism. NO is involved in appetite control, blood sugar regulation, inflammation, regulation of fat synthesis and breakdown, and the production of blood sugar in the liver. Products like Nitrosigine®, a patented, complex of arginine and silicon, are designed to increase NO levels and can help performance.

Regular physical activity is a major lifestyle factor enhancing the production of nitric oxide in the body. Recent discoveries in nitric oxide metabolism will facilitate development of new ingredients to help regulate weight control, improve exercise performance and promote quality of life. Nutrition 21 is at the forefront of research and development of mechanisms to enhance nitric oxide levels. Nitrosigine® is an advanced ingredient that works within 15 minutes and in a clinical study, significantly increased NO levels— providing a competitive edge to enhance performance by promoting blood flow and by increasing focus and energy. (Journal Sexual Medicine, 13: 808-814; Free Radical Biology and Medicine, 73: 383-399)